The perfusion cannula has a heating element, which is controlled by the temperature controller, so you can define the temperature of your solution. The first channel will transport your solution via the perfusion cannula to the sample. The peristaltic pump (PPS2) has two independent channels. Multi Channel Systems also offer a perfusion kit for enhanced perfusion, meaning the system can be extended with a heatable perfusion cannula, another temperature controller, and a peristaltic perfusion pump. You can select the desired temperature at the device itself or using the included control software TCx-Control. It is controlled by the included temperature controller, so the temperature of your sample is observed and kept stable at all times. In the MEA2100-headstage, there is a heating element right beneath the MEA. Please talk to your product consultant to find the right solution for your application. You can select the stimulation electrodes and design the signal shape via the included software.įor long-term recordings, Multi Channel Systems offers a variety of accessories: You can either cover the ring on the MEA with a semipermeable membrane or place a C02-chamber on the MEA slot. The headstage also provides an integrated stimulator, which can generate current or voltage stimulation signals on three independent channels (two for MEA2100-256-Systems) per MEA slot. The data is then sampled at 50 kHz/channel on all channels simultaneously, ensuring an excellent data quality. The built-in amplifier makes sure that the recorded signals are amplified close to the signal source, thereby minimizing noise. By closing the lid, the contact pads surrounding the MEA connect to the contact pins. The lid of the headstage can be opened easily and the MEA is placed in the headstage from the top. The rest of the setup is not affected, so changing the contact unit is simple, quick, and cost-effective. The contact unit of the MEA-headstage can be changed according to your experimental needs. You can either place one 60-electrode MEA, one 120-electrode MEA, one 256-electrode MEA or two 60-electrode MEAs in the headstage. MEA2100-headstages are available in different variants. It houses and heats the MEA, amplifies and digitizes the signals and has an integrated stimulus generator. The headstage is the core element of the system. Multiple inputs/outputs, including digital, analog, and audio.Real-time signal detection and feedback*.This leaves you with even more flexibility in switching between possible configurations for your specific research needs. It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. You can establish for example your experiments on 60, 120, or 256 electrodes with the MEA2100-System, then add the Multiwell-MEA-Headstage and start high-throughput screening. This makes cost-effective combinations with only one interface board and multiple recording systems possible. You can record from up to 4 MEAs in parallel, all at a sampling rate of 50 kHz per channel, ensuring an excellent data quality.įor more detailed information, please click on the description tab above.Īs part of the system, the IFB-C multiboot is a new interface board generation which is able to receive data from a MEA2100(-Mini)-Headstage, a Multiwell-MEA-Headstage, a CMOS-MEA5000-Headstage, a MEA2100-Beta-Screen-Headstage, a ME2100-Headstage, or a W2100-Receiver. Various headstage types facilitate the usage of different MEAs. The main advantage of the MEA2100-System is its flexibility. Today, the MEA2100-System is a very compact solution with integrated amplifier and stimulus generator, temperature control, and the option for real-time signal detection and feedback. Over the decades, many peer-reviewed articles have proven that the MEA technology is indeed a very powerful tool in electrophysiology research and the technology around the MEA has improved significantly. found that electrical activity can be recorded extracellularly with microelectrode arrays (MEA). It is based on an idea from the 1970’s, when Thomas et al. You can record from neuronal or cardiac cultures, stem cells, or brain or cardiac slices. The MEA2100-System is the most versatile in vitro recording system from Multi Channel Systems.
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